Dr. Lauranell Burch is a research scientist with a doctorate in Molecular Biology and Genetics from University of North Carolina at Chapel Hill.

Her 30+ year career has been focused on inflammatory and obstructive lung diseases, which includes cystic fibrosis, pulmonary fibrosis, COPD and asthma. During her career she has collaborated with the original researchers that uncovered the cystic fibrosis gene and has been responsible for the discovery of several mutations of the CFTR.

A document detailing Nell’s extensive work in discovering the CFTR gene known as 3849+10kbC>T can be downloaded at this link… http://www.nejm.org/doi/pdf/10.1056/NEJM199410133311503

For over 16 years she was employed as a scientist at the UNC’s Cystic fibrosis Center where she amassed extensive expertise in one of the premier airway epithelial cell culture facilities. Dr. Burch became expert in creating specialized cell culture models of the airway epithelial surface, which she later utilized in order to optimise nebulised therapies to more effectively treat airway surfaces.

In an endeavour to further her work on lung disease, Dr. Burch then joined Duke University, and was quickly promoted to the position of Senior Research Scientist in the Pulmonary, Allergy and Critical Care Medicine department where she used her ability to create and adapt valuable new technologies to research projects in pulmonary fibrosis, and concurrent management of several other pulmonary studies.

She was then recruited across to the National Institute of Environmental Health Sciences (NIEHS) in 2005, where she spent nine years studying environmental lung disease, and she served also as Director of the Molecular Genetics Core Facility there, as well as an agency-wide technical expert/advisor in bioinformatics, molecular biology, genetics and high-throughput methodologies.

Hoping to push past traditional barriers that had prevented rapid translation of her new ideas to patients, Dr. Burch joined Sharktank Research Foundation, a CF non-profit research Foundation, as their Scientific Director in 2014, and returned to UNC as Associate Professor of Diagnostic Sciences (adjunct) for the opportunity to work with mucosal biologist Dr. Roland Arnold, an expert in infection in mucosal surfaces and cystic fibrosis pathogens. Dr. Burch also established an off-campus lab where she volunteers much of her available time to Planetary Biosciences, a company that has been set up specifically to conduct collaborative research and development with the non profit Sharktank Research Foundation. Along with her colleagues, Dr. Burch’s goal is to develop novel drug therapies that transform cystic fibrosis from a fatal disease to a manageable condition with normal life expectancy and low lifestyle burden for treatments.

Following are some of the research projects and papers that Lauranell has authored or co-authored…

Identification of a splice site mutation (2789+5 G>A) associated with small amounts of normal CFTRmRNA and mild cystic fibrosis
W. Edward Highsmith Jr., Lauranell H. Burch, Zhaoqing Zhou, John C. Olsen, Theresa V. Strong, Terry Smith, Kenneth J. Friedman, Lawrence M. Silverman, Richard C. Boucher, Francis S. Collins, Michael R. Knowles http://dlx.booksc.org/00000000/libgen.scimag00065000-00065999.zip/browse/10.1002/%2528sici%25291098-1004%25281997%25299%253A4%253C332%253A%253Aaid-humu5%253E3.0.co%253B2-7.pdf

Innate Immunity Influences Long-term Outcomes after Human Lung Transplant
Scott M. Palmer, Lauranell H. Burch, Anil J. Trindade, R. Duane Davis, Walter F. Herczyk, Nancy L. Reinsmoen, and David A. Schwartz
http://download.docslide.net/getdownload/document/?id=RAzOVjLD4Exg0Z482unAr0n483lzCtZkccBXm4nb6VSiSzX%2F4HIwxdLT8X%2BBKkz1Td9O6KlOBKvri6y2FOvl9g%3D%3D

Histo-Blood Group Gene Polymorphisms as Potential Genetic Modifiers of Infection and Cystic Fibrosis Lung Disease Severity
AUTHORS: Taylor-Cousar, Jennifer L.; Zariwala, Maimoona A.; Burch, Lauranell H.; Pace, Rhonda G.; Drumm, Mitchell L.; Calloway, Hollin; Haiying Fan; Weston, Brent W.; Wright, Fred A.; Knowles, Michael R.
http://connection.ebscohost.com/c/articles/48217704/histo-blood-group-gene-polymorphisms-as-potential-genetic-modifiers-infection-cystic-fibrosis-lung-disease-severity

Ecto 5′-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways.
AUTHORS: Maryse Picher, Lauranell H Burch, Andrew J Hirsh, Josef Spychala, Richard C Boucher
https://www.citeab.com/publication/12560324-ecto-5-nucleotidase-and-nonspecific-alkaline-phosp

E-NTPDases in human airways: Regulation and relevance for chronic lung diseases
By Lauranell H. Burch and Maryse Picher
https://core.ac.uk/display/7800623

The IL-1 type 1 receptor is required for the development of LPS-induced airways disease 2007.
Authors Brass DM, Hollingsworth JW, Fessler MB, Savov JD, Maxwell AB, Whitehead GS, Burch LH, Schwartz DA.

The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. 2006.
Authors Burch LH, Yang IV, Whitehead GS, Chao FG, Berman KG, Schwartz DA.
https://www.ncbi.nlm.nih.gov/m/pubmed/16766576/

Metabolism of P2 receptor agonists in human airways: implications for mucociliary clearance and cystic fibrosis. 2004.
Authors Picher M, Burch LH, Boucher RC.
https://www.ncbi.nlm.nih.gov/m/pubmed/14993227/
Neutrophil elastase induces mucus cell metaplasia in mouse lung. 2004.
Authors: Voynow JA, Fischer BM, Malarkey DE, Burch LH, Wong T, Longphre M, Ho SB, Foster WM.
https://www.ncbi.nlm.nih.gov/m/pubmed/15273079/

In Vitro Production of Tumor Necrosis Factor-Alpha by Human Monocytes Stimulated with Lipopolysaccharide is Positively Correlated with Increased Blood Monocytes After Exposure to a Swine Barn
P. J. Willson , T. Talaei Khozani , B. H. J. Juurlink , A. Senthilselvan, D. C. Rennie, V. Gerdts, J. Gawaziuk , D. Schneberger, Lauranell H. Burch & J. A. Dosman
http://www.tandfonline.com/doi/abs/10.1080/15287390802241015

Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
Aimee K. Zaas, Guochun Liao, Jason W. Chien, Clarice Weinberg, David Shore, Steven S. Giles, Kieren A. Marr , Jonathan Usuka, Lauranell H. Burch, Lalith Perera, John R. Perfect, Gary Peltz, and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423485/

Fibroproliferation in LPS-induced airway remodeling and bleomycin-induced fibrosis share common patterns of gene expression
Authors David M. Brass, Ivana V. Yang, Marcus P. Kennedy, Gregory S. Whitehead, Holly Rutledge, Lauranell H. Burch, David A. Schwartz
https://link.springer.com/article/10.1007%2Fs00251-008-0293-3

Clinical and Pathologic Features of Familial Interstitial Pneumonia
Mark P. Steele, Marcy C. Speer, James E. Loyd, Kevin K. Brown, Aretha Herron, Susan H. Slifer, Lauranell H. Burch, Momen M. Wahidi, John A. Phillips, III, Thomas A. Sporn, H. Page McAdams, Marvin I. Schwarz, and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718398/#__ffn_sectitle

Damage-induced localized hypermutability
Lauranell H Burch, Yong Yang, […], and Dmitry A Gordenin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100884/

The Bacteriophage T4 Rapid-Lysis Genes and Their Mutational Proclivities
Lauranell H. Burch, Leilei Zhang, […], and John W. Drake
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133318/

IL-35 Production by ICOS+ Tregs Reverses Established IL-17-dependent Allergic Airways Disease
Gregory S. Whitehead, MSc,a Rhonda H. Wilson, PhD,aKeiko Nakano, Lauranell H. Burch, PhD, Hideki Nakano, PhD, and Donald N. Cook, PhDb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269135/#__ffn_sectitle

Spontaneous Mutations in Recombinant Inbred Mice: Mutant Toll-like Receptor 4 (Tlr4) in BXD29 Mice
Donald N. Cook,1 Gregory S. Whitehead, Lauranell H. Burch, Katherine G. Berman, Zareen Kapadia, Christine Wohlford-Lenane, and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456311/

The Environmental Polymorphism Registry: A Unique Resource that Facilitates Translational Research of Environmental Disease
Patricia C. Chulada,
Enrikas Vainorius,Stavros Garantziotis, Lauranell H. Burch, Perry J. Blackshear, and Darryl C. Zeldin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226495/

GENETIC BASIS OF MURINE RESPONSES TO HYPEROXIA-INDUCED LUNG INJURY
Gregory S. Whitehead, Lauranell H. Burch, […], and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892207/#__ffn_sectitle

Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia
Ivana V. Yang, Lauranell H. Burch, Mark P. Steele, Jordan D. Savov, John W. Hollingsworth, Erin McElvania-Tekippe, Katherine G. Berman, Marcy C. Speer, Thomas A. Sporn, Kevin K. Brown, Marvin I. Schwarz, and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899261/#__ffn_sectitle

The IL-1 type 1 receptor is required for the development of LPS-induced airways disease.
Brass DM, et al. J Allergy Clin Immunol. 2007.
Authors: Brass DM1, Hollingsworth JW, Fessler MB, Savov JD, Maxwell AB, Whitehead GS, Burch LH, Schwartz DA.
https://www.ncbi.nlm.nih.gov/m/pubmed/17512577/
The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment.
Authors: Burch LH1, Yang IV, Whitehead GS, Chao FG, Berman KG, Schwartz DA.
https://www.ncbi.nlm.nih.gov/m/pubmed/16766576/
Damage-induced localized hypermutability
Lauranell H Burch,#1 Yong Yang,#1,† Joan F Sterling,1 Steven A Roberts,1 Frank G Chao,1 Hong Xu,1 Leilei Zhang,1 Jesse Walsh,2 Michael A Resnick,1 Piotr A Mieczkowski, and Dmitry A Gordenin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100884/#__ffn_sectitle

The Bacteriophage T4 Rapid-Lysis Genes and Their Mutational Proclivities ▿
Lauranell H. Burch, Leilei Zhang, Frank G. Chao, Hong Xu, and John W. Drake*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133318/#!po=74.5614

IL-35 Production by ICOS+ Tregs Reverses Established IL-17-dependent Allergic Airways Disease
Gregory S. Whitehead, MSc,a Rhonda H. Wilson, PhD,aKeiko Nakano, Lauranell H. Burch, PhD, Hideki Nakano, PhD, and Donald N. Cook, PhDb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269135/#__ffn_sectitle
Spontaneous Mutations in Recombinant Inbred Mice: Mutant Toll-like Receptor 4 (Tlr4) in BXD29 Mice
Donald N. Cook,1 Gregory S. Whitehead, Lauranell H. Burch, Katherine G. Berman, Zareen Kapadia, Christine Wohlford-Lenane, and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456311/#__ffn_sectitle
GENETIC BASIS OF MURINE RESPONSES TO HYPEROXIA-INDUCED LUNG INJURY
Gregory S. Whitehead, Lauranell H. Burch, […], and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892207/
Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia
Ivana V. Yang, Lauranell H. Burch, […], and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899261/

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy C. EDWARD PARR*, DANIEL M. SULLIVANt, ANTHONY M. PARADISO*, EDUARDO R. LAZAROWSKI*, LAURANELL H. BURCH*, JOHN C. OLSEN*, LAURIE ERB*, GARY A. WEISMANt, RICHARD C. BOUCHER*, AND JOHN T. TURNER
http://www.pnas.org/content/91/8/3275.full.pdf
Finding Fibrosis Genes
Lauranell H. Burch
David A. Schwartz
https://link.springer.com/protocol/10.1385/1-59259-940-0:293
IL-35 PRODUCTION BY INDUCIBLE COSTIMULATOR (ICOS)-POSITIVE REGULATORY T CELLS REVERSES ESTABLISHED IL-17-DEPENDENT ALLERGIC AIRWAYS DISEASE. 2011 Sep 8.
Gregory S Whitehead, Rhonda H Wilson, Keiko Nakano, Lauranell H Burch, Hideki Nakano, Donald N Cook
http://www.jacionline.org/article/S0091-6749(11)01286-3/fulltext

THE ENVIRONMENTAL POLYMORPHISM REGISTRY: A UNIQUE RESOURCE THAT FACILITATES TRANSLATIONAL RESEARCH OF ENVIRONMENTAL DISEASE. 2011
Patricia C Chulada, Enrikas Vainorius, Stavros Garantziotis, Lauranell H Burch, Perry J Blackshear, Darryl C Zeldin
https://www.ncbi.nlm.nih.gov/m/pubmed/21659040/

TOLL-LIKE RECEPTOR 4 ASP299GLY AND THR399ILE POLYMORPHISMS AND TYPHOID SUSCEPTIBILITY IN ASIAN MALAY POPULATION IN MALAYSIA.
Microbes Infect 2011 Sep 12;13(10):844-51. Epub 2011 May 12.
Saatheeyavaane Bhuvanendran, Hani M Hussin, Lila P Meran, Amy A Anthony, Leilei Zhang, Lauranell H Burch, Kia K Phua, Asma Ismail, Prabha Balaram

THE BACTERIOPHAGE T4 RAPID-LYSIS GENES AND THEIR MUTATIONAL PROCLIVITIES.
J Bacteriol 2011 Jul 13;193(14):3537-45. Epub 2011 May 13.
Lauranell H Burch, Leilei Zhang, Frank G Chao, Hong Xu, John W Drake

DAMAGE-INDUCED LOCALIZED HYPERMUTABILITY.
Cell Cycle 2011 Apr 1;10(7):1073-85. Epub 2011 Apr 1.
Lauranell H Burch, Yong Yang, Joan F Sterling, Steven A Roberts, Frank G Chao, Hong Xu, Leilei Zhang, Jesse Walsh, Michael A Resnick, Piotr A Mieczkowski, Dmitry A Gordenin

NOVEL REGULATORS OF THE SYSTEMIC RESPONSE TO LIPOPOLYSACCHARIDE.
Am J Respir Cell Mol Biol 2011 Aug 3;45(2):393-402. Epub 2010 Dec 3.
Ivana V Yang, Scott Alper, Brad Lackford, Holly Rutledge, Laura A Warg, Lauranell H Burch, David A Schwartz

GENETIC VARIATION IN SOLUBLE EPOXIDE HYDROLASE (EPHX2) IS ASSOCIATED WITH FOREARM VASODILATOR RESPONSES IN HUMANS.
Hypertension 2011 Jan 22;57(1):116-22. Epub 2010 Nov 22.
Craig R Lee, Mias Pretorius, Robert N Schuck, Lauranell H Burch, Jackie Bartlett, Scott M Williams, Darryl C Zeldin, Nancy J Brown

GENDER-RELATED TUMOR NECROSIS FACTOR-ALPHA RESPONSES IN NAÏVE VOLUNTEERS WITH TOLL-LIKE RECEPTOR 4 POLYMORPHISMS EXPOSED IN A SWINE CONFINEMENT FACILITY.
J Interferon Cytokine Res 2009 Dec;29(12):781-90
Ambikaipakan Senthilselvan, Liliane Chénard, Shelley Kirychuk, Bernardo Predicala, David A Schwartz, Lauranell H Burch, Donna C Rennie, Philip J Willson, James A Dosman

TOLL-LIKE RECEPTOR 4 VARIANTS REDUCE AIRWAY RESPONSE IN HUMAN SUBJECTS AT HIGH ENDOTOXIN LEVELS IN A SWINE FACILITY.
J Allergy Clin Immunol 2009 May 14;123(5):1034-40, 1040.e1-2. Epub 2009 Apr 14.
Ambikaipakan Senthilselvan, James A Dosman, Liliane Chénard, Lauranell H Burch, Bernardo Z Predicala, Randine Sorowski, David Schneberger, Tom Hurst, Shelley Kirychuk, Volker Gerdts, Yvon Cormier, Donna C Rennie, David A Schwartz

HISTO-BLOOD GROUP GENE POLYMORPHISMS AS POTENTIAL GENETIC MODIFIERS OF INFECTION AND CYSTIC FIBROSIS LUNG DISEASE SEVERITY.
PLoS One 2009 26;4(1):e4270. Epub 2009 Jan 26.
Jennifer L Taylor-Cousar, Maimoona A Zariwala, Lauranell H Burch, Rhonda G Pace, Mitchell L Drumm, Hollin Calloway, Haiying Fan, Brent W Weston, Fred A Wright, Michael R Knowles,

IN VITRO PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA BY HUMAN MONOCYTES STIMULATED WITH LIPOPOLYSACCHARIDE IS POSITIVELY CORRELATED WITH INCREASED BLOOD MONOCYTES AFTER EXPOSURE TO A SWINE BARN.
J Toxicol Environ Health A 2008 ;71(21):1401-6
P J Willson, T Talaei Khozani, B H J Juurlink, A Senthilselvan, D C Rennie, V Gerdts, J Gawaziuk, D Schneberger, Lauranell H Burch, J A Dosman

PLASMINOGEN ALLELES INFLUENCE SUSCEPTIBILITY TO INVASIVE ASPERGILLOSIS.
PLoS Genet 2008 Jun 20;4(6):e1000101. Epub 2008 Jun 20.
Aimee K Zaas, Guochun Liao, Jason W Chien, Clarice Weinberg, David Shore, Steven S Giles, Kieren A Marr, Jonathan Usuka, Lauranell H Burch, Lalith Perera, John R Perfect, Gary Peltz, David A Schwartz

FIBROPROLIFERATION IN LPS-INDUCED AIRWAY REMODELING AND BLEOMYCIN-INDUCED FIBROSIS SHARE COMMON PATTERNS OF GENE EXPRESSION.
Immunogenetics 2008 Jul 13;60(7):353-69. Epub 2008 Jun 13.
David M Brass, Ivana V Yang, Marcus P Kennedy, Gregory S Whitehead, Holly Rutledge, Lauranell H Burch, David A Schwartz

ASSOCIATION OF POLYMORPHISMS OF TOLL-LIKE RECEPTOR 4 WITH A REDUCED PREVALENCE OF HAY FEVER AND ATOPY.
Ann Allergy Asthma Immunol 2008 May;100(5):463-8
Ambikaipakan Senthilselvan, Donna Rennie, Liliane Chénard, Lauranell H Burch, Lorne Babiuk, David A Schwartz, James A Dosman

E-NTPDASES IN HUMAN AIRWAYS: REGULATION AND RELEVANCE FOR CHRONIC LUNG DISEASES.
Purinergic Signal 2006 Jun 30;2(2):399-408. Epub 2006 May 30.
Lauranell H Burch, Maryse Picher

THE IL-1 TYPE 1 RECEPTOR IS REQUIRED FOR THE DEVELOPMENT OF LPS-INDUCED AIRWAYS DISEASE.
J Allergy Clin Immunol 2007 Jul 18;120(1):121-7. Epub 2007 May 18.
David M Brass, John W Hollingsworth, Michael B Fessler, Jordan D Savov, Abby B Maxwell, Gregory S Whitehead, Lauranell H Burch, David A Schwartz

GENETIC BASIS OF MURINE RESPONSES TO HYPEROXIA-INDUCED LUNG INJURY.
Immunogenetics 2006 Oct 26;58(10):793-804. Epub 2006 Sep 26.
Gregory S Whitehead, Lauranell H Burch, Katherine G Berman, Claude A Piantadosi, David A Schwartz

GENE EXPRESSION PROFILING OF FAMILIAL AND SPORADIC INTERSTITIAL PNEUMONIA.
Am J Respir Crit Care Med 2007 Jan 22;175(1):45-54. Epub 2006 Sep 22.
Ivana V Yang, Lauranell H Burch, Mark P Steele, Jordan D Savov, John W Hollingsworth, Erin McElvania-Tekippe, Katherine G Berman, Marcy C Speer, Thomas A Sporn, Kevin K Brown, Marvin I Schwarz, David A Schwartz

THE TRANSCRIPTIONAL RESPONSE TO LIPOPOLYSACCHARIDE REVEALS A ROLE FOR INTERFERON-GAMMA IN LUNG NEUTROPHIL RECRUITMENT.
Am J Physiol Lung Cell Mol Physiol 2006 Oct 9;291(4):L677-82. Epub 2006 Jun 9.
Lauranell H Burch, Ivana V Yang, Gregory S Whitehead, Frank G Chao, Katherine G Berman, David A Schwartz

DONOR POLYMORPHISMS IN TOLL-LIKE RECEPTOR-4 INFLUENCE THE DEVELOPMENT OF REJECTION AFTER RENAL TRANSPLANTATION.
Clin Transplant 2006 Jan-Feb;20(1):30-6
Scott M Palmer, Lauranell H Burch, Saad Mir, Stephen R Smith, Paul C Kuo, Walter F Herczyk, Nancy L Reinsmoen, David A Schwartz

SPONTANEOUS MUTATIONS IN RECOMBINANT INBRED MICE: MUTANT TOLL-LIKE RECEPTOR 4 (TLR4) IN BXD29 MICE.
Genetics 2006 Mar 1;172(3):1751-5. Epub 2005 Dec 1.
Donald N Cook, Gregory S Whitehead, Lauranell H Burch, Katherine G Berman, Zareen Kapadia, Christine Wohlford-Lenane, David A Schwartz

FINDING FIBROSIS GENES: THE LUNG.
Methods Mol Med 2005 ;117:293-313
Lauranell H Burch, David A Schwartz

CLINICAL AND PATHOLOGIC FEATURES OF FAMILIAL INTERSTITIAL PNEUMONIA.
Am J Respir Crit Care Med 2005 Nov 18;172(9):1146-52. Epub 2005 Aug 18.
Mark P Steele, Marcy C Speer, James E Loyd, Kevin K Brown, Aretha Herron, Susan H Slifer, Lauranell H Burch, Momen M Wahidi, John A Phillips, Thomas A Sporn, H Page McAdams, Marvin I Schwarz, David A Schwartz

INNATE IMMUNITY INFLUENCES LONG-TERM OUTCOMES AFTER HUMAN LUNG TRANSPLANT.
Am J Respir Crit Care Med 2005 Apr 7;171(7):780-5. Epub 2005 Jan 7.
Scott M Palmer, Lauranell H Burch, Anil J Trindade, R Duane Davis, Walter F Herczyk, Nancy L Reinsmoen, David A Schwartz

LOSS-OF-FUNCTION MUTATION IN TRYPTOPHAN HYDROXYLASE-2 IDENTIFIED IN UNIPOLAR MAJOR DEPRESSION.
Neuron 2005 Jan;45(1):11-6
Xiaodong Zhang, Raul R Gainetdinov, Jean-Martin Beaulieu, Tatyana D Sotnikova, Lauranell H Burch, Redford B Williams, David A Schwartz, K Ranga R Krishnan, Marc G Caron

ONTOGENESIS OF MYOSIN LIGHT CHAIN KINASE MRNA AND PROTEIN CONTENT IN GUINEA PIG TRACHEAL SMOOTH MUSCLE.
Pediatr Pulmonol 2004 Dec;38(6):456-64
Pasquale Chitano, Judith A Voynow, Valeria Pozzato, Viviana Cantillana, Lauranell H Burch, Lu Wang, Thomas M Murphy

NEUTROPHIL ELASTASE INDUCES MUCUS CELL METAPLASIA IN MOUSE LUNG.
Am J Physiol Lung Cell Mol Physiol 2004 Dec 23;287(6):L1293-302. Epub 2004 Jul 23.
Judith A Voynow, Bernard M Fischer, David E Malarkey, Lauranell H Burch, Teresa Wong, Malinda Longphre, Samuel B Ho, W Michael Foster

METABOLISM OF P2 RECEPTOR AGONISTS IN HUMAN AIRWAYS: IMPLICATIONS FOR MUCOCILIARY CLEARANCE AND CYSTIC FIBROSIS.
J Biol Chem 2004 May 1;279(19):20234-41. Epub 2004 Mar 1.
Maryse Picher, Lauranell H Burch, Richard C Boucher

THE ROLE OF INNATE IMMUNITY IN ACUTE ALLOGRAFT REJECTION AFTER LUNG TRANSPLANTATION.
Am J Respir Crit Care Med 2003 Sep 28;168(6):628-32. Epub 2003 May 28.
Scott M Palmer, Lauranell H Burch, R Duane Davis, Walter F Herczyk, David N Howell, Nancy L Reinsmoen, David A Schwartz

ECTO 5′-NUCLEOTIDASE AND NONSPECIFIC ALKALINE PHOSPHATASE. TWO AMP-HYDROLYZING ECTOENZYMES WITH DISTINCT ROLES IN HUMAN AIRWAYS.
J Biol Chem 2003 Apr 30;278(15):13468-79. Epub 2003 Jan 30.
Maryse Picher, Lauranell H Burch, Andrew J Hirsh, Josef Spychala, Richard C Boucher

The Role of Innate Immunity in Acute Allograft Rejection after Lung … – ATS Journals
www.atsjournals.org › doi › pdf
by SM Palmer – ‎2003 – ‎Cited by 180 – ‎Related articles
Mar 28, 2003 – Scott M. Palmer, Lauranell H. Burch, R. Duane Davis, Walter F. Herczyk, …. obstructive pulmonary disease, cystic fibrosis, and idiopathic pul-.

Histo-Blood Group Gene Polymorphisms as Potential Genetic Modifiers of Infection and Cystic Fibrosis Lung Disease Severity
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004270
Jennifer L. Taylor-Cousar, Maimoona A. Zariwala, Lauranell H. Burch, Rhonda G. Pace, Mitchell L. Drumm, Hollin Calloway, […view 4 more…], for the Gene Modifier Study Group

IL-35 production by inducible costimulator (ICOS)–positive regulatory T cells reverses established IL-17–dependent allergic airways disease
http://www.jacionline.org/article/S0091-6749(11)01286-3/fulltext
Gregory S. Whitehead, MSc∗, Rhonda H. Wilson, PhD∗, Keiko Nakano, BSc, Lauranell H. Burch, PhD, Hideki Nakano, PhD, Donald N. Cook, PhD

P2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways
Lubna H. ABDULLAH, Shannon W. DAVIS, Lauranell BURCH, Mitsuo YAMAUCHI, Scott H. RANDELL, Paul NETTESHEIM, C. William DAVIS
Biochemical Journal
Jun 15, 1996,
316
(3)
943-951;
DOI:10.1042/bj3160943

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and typhoid susceptibility in Asian Malay population in Malaysia.
Bhuvanendran S, et al. Microbes Infect. 2011.
Authors
Bhuvanendran S1, Hussin HM, Meran LP, Anthony AA, Zhang L, Burch LH, Phua KK, Ismail A, Balaram P.

1.

2. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitmentLauranell H Burch
National Institute of Environmental Health Sciences, Division of Pulmonary, Allergy, and Critical Care Medicine, Research Triangle Park, NC 27709, USA
Am J Physiol Lung Cell Mol Physiol 291:L677-82. 2006

3.

4. The IL-1 type 1 receptor is required for the development of LPS-induced airways diseaseDavid M Brass
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Allergy Clin Immunol 120:121-7. 2007

5. Gene expression profiling of familial and sporadic interstitial pneumoniaIvana V Yang
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, P O Box 12233, MD B3 08, Research Triangle Park, NC 27909, USA
Am J Respir Crit Care Med 175:45-54. 2007

6. Genetic basis of murine responses to hyperoxia-induced lung injuryGregory S Whitehead
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Immunogenetics 58:793-804. 2006

7. The Environmental Polymorphism Registry: a unique resource that facilitates translational research of environmental diseasePatricia C Chulada
Clinical Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Environ Health Perspect 119:1523-7. 2011

8. Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 miceDonald N Cook
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 172:1751-5. 2006

9. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways diseaseGregory S Whitehead
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Allergy Clin Immunol 129:207-15.e1-5. 2012

10. The bacteriophage T4 rapid-lysis genes and their mutational proclivitiesLauranell H Burch
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Bacteriol 193:3537-45. 2011

11.

12. Finding fibrosis genes: the lungLauranell H Burch
Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
Methods Mol Med 117:293-313. 2005

13. Damage-induced localized hypermutabilityLauranell H Burch
National Institute of Environmental Health Sciences, Research Triangle Park, NC USA
Cell Cycle 10:1073-85. 2011

GENETIC BASIS OF MURINE RESPONSES TO HYPEROXIA-INDUCED LUNG INJURY
Gregory S. Whitehead, Lauranell H. Burch, […], and David A. Schwartz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892207/